Abstract: The synthetic methods for 1,3-diazido-2-nitro-2-azapropane (DANP) from urea and its derivatives are reviewed herein. A synthetic route to DANP from N,N’-dinitrourea has been devised on the basis of the study results, which can reduce the number of stages to the three, exclude acetic anhydride and its mixture with nitric acid from the process, shorten the synthesis time, and improve the total yield to 31%. Pure N,N’-dinitrourea used was noticed to enhance the stability of the intermediates in the DANP synthesis and make the purification process (1,3-diacetoxy- and 1,3-dichloro-2-nitro-2-azapropane) via vacuum distillation more high-tech and the used substituted nitramines more affordable. The findings open the door to designing compounds with tailored structure and properties, which are of interest to defense industry.
Index terms: aliphatic nitramines, 1,3-diazido-2-nitro-2-azapropane, N,N’-dinitrourea, 1,3-dihydroxy-2-nitro-2-azapropane, 1,3-dichloro-2-nitro-2-azapropane.