Index terms: synthesis, substrate concentration, gas solubility, mixing, oxygen solubility.
Abstract: This article describes the synthesis model of the cultivation process. This method allows you to adjust the degree of aeration and it is amount. The method of exchanging the products of cell activity for microorganisms. The article presents the processes of mass transfer and hydrodynamics in the apparatus for the cultivation of microorganisms, which directly affect the calculations of the velocities of the liquid phase in the gaseous-bone flow. The gas-liquid flow velocity depends on the gas velocity, the physical and chemical properties of the medium, the viscosity of the medium, the gas content in the bubbling and circulating medium, and other parameters of hydraulics and hydrodynamics.

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