OZONE / NO-ULTRASONIC METHOD IN COMBINATION WITH PHOTOCHROM RADIATION AND ANTIOXIDANTS IN THE TREATMENT OF PATIENTS WITH AGE-RELATED MACULAR DEGENERATION OF THE RETINA

V.V. Pedder, A.A. Golubitskikh, E.V. Khrustaleva, R.N. Golykh, S.I. Postolnik, E.G. Galyanskaya
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Abstract: Today, age-related macular degeneration of the retina (AMD) is one of the leading causes of vision disability. The disease is characterized by a predominant lesion of the choriocapillary layer, Bruch's membrane and retinal pigment epithelium, followed by the involvement of photoreceptors. Over the past decade, there has been a significant increase in the incidence of this pathology both in old and young age. Distinguish between dry and wet form of AMD. Damaging factors of various etiologies trigger a cascade of pathogenetic reactions that lead to irreversible loss of central vision. In the pathogenesis of the disease, an essential role belongs to oxidative stress, due to an imbalance between oxidative and antioxidant systems, which causes a violation of the integrity of the complex of photoreceptors and retinal pigment epithelium. Violation of microcirculation in the outer layers of the retina leads to the accumulation of endotoxins. The lymphatic system, as one of the most important sanogenic-potential functions of the body, is involved in the relief of endotoxicosis in patients with AMD due to the lymphatic sorption of toxins directly in the tissues with the help of the lymphatic capillaries of the interested lymph region. The lack of sufficiently effective methods for treating macular degeneration of the retina, allowing to increase visual function and prevent the progression of blindness in patients, stimulates the search for methods that use a complex effect on pathologically altered eye tissues. The article presents the rationale for the combined ozone / NO-ultrasound method in combination with photochromic and laser radiation and antioxidants in the treatment of macular degeneration of the retina, allowing to influence the retina, both through the nasal mucosa and superficially through the skin of the face and neck in zainte -resolved areas of the projections of the lymph nodes and interstitium along the lymphatic vessels diverting from the visual analyzer. The proposed method of treating patients with AMD allows for a combined therapeutic effect of a complex of physical and physicochemical factors on the dystrophically altered retina to arrest the pathological process.
Index terms: age-related macular degeneration, ozone, nitric oxide, ultrasound, photochromic and laser radiation, antioxidants.

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